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Calm & Clever Calm & Clever Calm & Clever

Calm & Clever

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$28.50
/ 30 day supply
In Stock. Free shipping on orders over $40

    NEW!
    We added 334mg of Sage (Salvia officinalis) standardized
    extract for enhanced memory and cognitive benefits!

    • Reduces physical and psychological impacts of stress
    • Improves cell-mediated immunity
    • Calms occasional anxiety and promotes a positive mind
    • Enhances cognitive function and brain health
    • Boosts mental alertness and focus throughout the day
    • Improves both quantity and quality of sleep*

Calm & Clever helps reduce the negative psychological and physiological effects of stress in everyday life, as well as a whole host of unwanted health concerns that can happen as a result of too much stress. This advanced formula contains clinically researched amounts of key ingredients to ensure benefits:

  • Helps reduce cortisol levels, the primary stress response hormone
  • Supports healthy immune response; improves cell-mediated immunity
  • Enhances cognitive brain function
  • Increases ability to think more clearly
  • Increased memory of facts and word recall
  • Ability to perform challenging tasks when subjected to stress
  • Supports falling asleep more easily and staying asleep for longer periods without waking

Calm & Clever is effective for students, busy moms and dads, professionals, athletes, and the elderly. Anyone experiencing stress, occasional anxiety, occasional memory and recall difficulty, and unsettled sleep will benefit from Calm & Clever.

Calm & Clever was formulated by Curt Hendrix M.S. C.C.N. C.N.S., Akeso's Scientific Officer. Curt holds advanced degrees in chemistry and clinical nutrition and his extensive research in the field of neurological disorders has earned him grants from the US government’s National Institutes of Health for the study of Alzheimer’s.

Learn More in our Health Library 

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The ingredients in Calm & Clever™ have been clinically studied to reduce the negative psychological and physiological effects of stress in everyday life.

Ingredients: Serving size 2 caplets

Per Serving
Vitamin C (Ascorbic Acid)                       250 mg 
Vitamin B-6 (Pyridoxal-5-Phosphate)     25 mg 
Pantothenic Acid                                      30 mg 
Bacopa Monnieri (50% Bacosides)        320 mg
Huperzine A                                            200 mcg 
Ashwagandha Extract                            600 mg   
    (KSM-66, 5% withanolides)
Sage Extract (Salvia officinalis)               167 mg
    (standardized 2.5% Rosmarinic acid) 

NO wheat, corn, sugar, soy, dairy, yeast, or artificial flavors. Gluten Free | Vegan


Ascorbic Acid (Vitamin C)
Well known for its immune-protecting abilities, studies also link high vitamin C intake with improved mental function and reduced memory loss. A deficiency of vitamin C reduces production of neurotransmitters associated with anxiety.*

  • Helps protect mental clarity and memory
  • Helps produce neurotransmitters (chemicals that affect our mind and mood)
  • Helps fight against age related memory loss and some forms of dementia

Pyridoxal-5-phosphate (metabolically active form of vitamin B-6) 
According to studies, supplementation with B-6 helps lessen age-related cognitive decline (e.g., perception, attention, reaction time, and memory)

  • Supports healthy homocysteine levels (HCY)—elevated HCY levels are associated with brain shrinkage, cognitive decline and performance
  • Important for nervous system functions
  • Needed in the synthesis of neurotransmitters like serotonin
  • Helps offset the effects of sugar (glycation), ages all cells and organs in the body including the brain and nerves

    Pantothenic Acid (Vitamin B5)
    Vitamin B-5 produces numerous enzymes and helps maintain communication between the central nervous system and the brain. A low level of B5 can lead to difficulty coping with stress, inability to relax and problems sleeping.*

    • Regulates stress-related hormones to ensure a healthy state of mind
    • Builds immune system
    • Stamina builder helping to fight fatigue
    • Helps protect mental clarity and memory
    • Helps make neurotransmitters (chemicals that affect our mind and mood)

    Bacopa Monnieri (Brahmi)
    A well-known herb in Ayurvedic traditional medicine to improve memory and intelligence. Clinical studies suggest that bacopa may improve the retention of learned facts and memory. After 4 weeks of use, bacopa was shown to reduce nervousness and irritability in humans with occasional anxiety.*

    • Maintains health brain chemistry
    • Stimulates vital neurotransmitters that process information
    • Reduces symptoms of anxiety
    • Improves concentration

    Huperzine-A
    Huperzine-A is a neuro-nutrient compound known to nutritionally support normal memory, cognitive function, and behavioral function in healthy patients, as well as in patients with Alzheimer’s, mild cognitive impairment, and those with elderly dementia.*

    Ashwagandha (Withania Somnifera)
    KSM-66 is a full spectrum ashwagandha extract derived from only the most valuable part of the plant, the roots! Ashwagandha is an adaptogen and the most popular traditional medicine plant used by Ayurvedic practitioners. Backed by scientific human studies and published in respected, peer-reviewed journals.

    • Supports and maintains normal, healthy memory and cognitive function
    • Supports the body's immune system
    • Supports the mind against the effects of stress and anxiety
    • Provides better recall of facts, names and numbers
    • Stabilizes hormones associated with stress and anxiety
    • Significant reduction in scores on Stress Assessment Scales within 60 days —with an increase in self-assessed quality of life
    • Supports normal healthy sexual response and function*

    Sage Extract
    Sage (Salvia officinalis), has been used to improve memory for centuries. Extensive scientific research has been done on the value of sage for enhancing cognition performance and for improving mood, which have been observed in those with cognitive deficits and also in healthy people. Sage also acts as an anti-oxidant and supports a healthy inflammatory response.*

    * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

    Calm & Clever contains effective, clinically researched amounts of key ingredients to support stress reduction and occasional anxiety, plus enhance cognitive function, brain health, and mental clarity throughout the day.

    Recommended Use: Daily Formula | Clinical Strength

    Take 2 caplets a day with food.

    Benefits can be experienced in as few as 1-2 days.

    Please allow 2-3 weeks to achieve optimal benefits. Then continue daily use. 

    Caution:  As with all dietary supplements, consult with your physician before use.
    Not recommended for children under 10, or pregnant or lactating women. 

    Keep out of reach of children.

     NO wheat, corn, sugar, soy, dairy, yeast, or artificial flavors. Gluten Free. Vegan.

    * These statements have not been evaluated by the Food and Drug Administration.
    This product is not intended to diagnose, treat, cure, or prevent any disease.
    1. Plevin, D., Galletly, C. The neuropsychiatric effects of vitamin C deficiency: a systematic review. BMC Psychiatry 20, 315 (2020). https://doi.org/10.1186/s12888-020-02730-w
    2. Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med. 2009;46(6):719-730
    3. Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition. 2010. [E pub ahead of print
    4. Navneet Kumar,L. G. Abichandani,Vijay Thawani, 3 K. J. Gharpure,  M. U. R. Naidu, and G. Venkat Ramana . Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial. PMID: 27803728
    5. Chuenjid Kongkeaw, Piyameth Dilokthornsakul,Phurit Thanarangsarit, Nanteetip Limpeanchob, C Norman Scholfield. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. PMID: 24252493
    6. Sangeeta Raghav, Harjeet Singh, P.K. Dalal, J.S. Srivastava, and O.P. Asthana
    7. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. PMCID: PMC2915594
    8. Sebastian Aguiar and Thomas Borowski. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. 2013 Aug; 16(4): 313–326, PMID: 23772955
    9. Adrian L. Lopresti. Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects. 2016 Nov 25. PMID: 27888449
    10. Ragav, S, Singh, H, Dalal P. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006;48(4):238-242
    11. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002;27(2):279

    Meet the Scientist Behind Our Products

    Curt Hendrix, MS, CCN, CNS

    Curt, our co-founder, is passionate about helping people with chronic health issues. He has dedicated his life to the research and development of natural medicines. With degrees in chemistry and clinical nutrition, Curt has been studying the chemistry of disease for over 30 years.



    Researchers around the world cite Curt's published scientific research. He is well known for his extensive knowledge in the field of neurological disorders, including Alzheimer's. The U.S. National Institutes of Health trusted Curt with several grants and patents.



    Curt believes that evidence-based science is the key to effective natural medicines.