Effective Nutritional Support for Women Experiencing Menstrual, PMS, Menopausal, and Hormonal Fluctuations Contributing to Migraines
MigreLief+Mwas researched and developed as an effective combination of 8 key ingredients shown in human clinical studies to balance already normal blood sugar levels and hormones when women are most susceptible to migraines: during monthly menstruation, the reproductive years, and during perimenopause and menopause.*
TheMigreLief+Mformula supports with the following hormone related symptoms:
Irregular menstrual cycles*
MigreLief+M is based on the only original patented material successfully used by hundreds of thousands of customers worldwide for more than 20 years, and is recommended by headache specialists and other healthcare professionals.
Effective for daily use—non-prescription and drug free
Does not contain butterbur, wheat, gluten, salt, soy, milk or dairy, nuts, corn, caffeine, or artificial flavorings or preservatives. Non-GMO. Vegan.
*This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
MigreLief+MIS A TRUSTED FORMULA THAT MAKES A DIFFERENCE
60 Caplets / 2 per day / 1-month supply
Amount per day
Riboflavin (Vitamin B-2)
Magnesium (citrate and oxide)
Pyridoxine Hydrochloride (Vitamin B-6)
Biotin (biotin-d, 15,000mcg)
Puracol® Feverfew** (Tanacetum parthenium)
*No Daily Value established
Puracol® Feverfew (Tanacetum parthenium)is a proprietary combination of whole leaf feverfew high in naturally occurring phytochemicals and a special feverfew extract. Supports proper cerebrovascular tone and function, and platelet aggregation that can otherwise lead to vasoconstriction.*
Riboflavin—high doses of Riboflavin have been proven in clinical studies to reduce the number of neurological discomforts experienced each month and improve mitochondrial energy deficiencies.*
Magnesium—two clinically known beneficial forms critical to controlling the inhibition of vasospasm.*
Chasteberry Extract—has been shown in numerous studies to establish balance of female hormones, and reduce discomfort, excessive bleeding, and signs of PMS and POCS
L-Theanine—L-theanine is an amino acid known to calm without making you drowsy, increase alpha wave activity in the brain, and lessens signs of PMS.*
D-Biotin—higher amounts of biotin is required to stabilize blood sugar levels, which is strongly related to the occurrence of migraines, and the symptoms of PMS and PCOS*
Pyridoxine Hydrochloride (vitamin B-6)—Multiple human studies (listed below) in almost 1000 women, have shown that vitamin B-6 helps to alleviate PMS discomforts, irritability, low mood, cravings and bloating.*
Chromium—an essential trace mineral that can improve insulin sensitivity and enhance protein, carbohydrate, and lipid metabolism
Akeso's MigreLief® line of products has changed lives worldwide by providing effective nutritional support to migraine sufferers.
MigreLief+M is effective for females experiencing menstrual and PMS, hormonal fluctuations, or perimenopausal and menopausal symptoms contributing to migraines.
Take one caplet twice a day for 90 days during the build-up period.
To maintain benefits, continue daily use. For as-needed additional support and comfort, try adding MigreLief-NOWfollowing recommended use directions for that product.
Caution: Not recommended for use during pregnancy, during lactation, or for young females prior to menstruation.
• Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
• Although rare, some individuals experience transient (short term) diarrhea when taking magnesium.
• Like most dietary supplements, use of MigreLief+M should be discontinued one week before any surgery.
Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
Lawrence Review of Natural Products, September 1994.
Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Pharm Pharmacol 1988; 40-743-5.
Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine–A Double-Blind, Placebo-Controlled Study. Cephalalgia 1996;16:436-40.
Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
Maria Condò1, Annio Posar1, Annalisa Arbizzani1 and Antonia Parmeggiani1 Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009
Schellenberg R. Treatment for PMS with agnus castus. BMJ. 2001 Han 20;322(7279):134-7
Haut-und Gesch. 1964; 36:220 Giss, G. Rothenburg,W.
Ggw 1967;106:124-6 Amann W. Improvement of acne vulgaris with Agnus castus
Zbl GynSkol 1959 81:701 Bleier, W.
Medica Emperica 1990, 9”494-502 Bohnert, K.J. Hahs, G. Phytotherapy in Gynecology and Obstetrics (Chasteberry) Acta
clin. Biochem Nutr. 1993;14:211-218 Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus.
2007 Nov-Dec;47(10):1436-43 Insulin metabolism is altered in migraineurs. Cavestro, C. et al
J Obstet Gynaecol 1990;97:847-52 vitamin B6 in the treatment of the premenstrual syndrome- a review, Kleijnen J. Riet GT et al
Int J]. Gunn AD Vitam Nutr Res. 1985;Suppl 27:213–24 review
J Int Med Res 1985;13:174-9 Controlled trial of B6 in PMS Harris RI, Deand BC
Lancet 1985;1399 B6 and PMS Brush MG, Perry M.
BMJ 1999;318;1375-81 Systematic Review B6 and PMS Dimmock PW et al
Arch Dermatol 1974;110:130-131 B6 for premenstrual acne Snider B et al
J Invest Dermatol 1942;5:143-8 B6 on resistant adolescent acne. Joliffe N et al
Clin Neuropharmacol 30(1):25-38 Electrical mapping of the effect of theanine. Higgin BA et al
Bio Psychol 74(1):39-45 Theanine reduces psychological and physiological stress Ozeki M et al.
Biol Psychol 77(2):113-22 Effects of theanine and caffeine on cognition and mood Kimura k et al.