4.8
Rated 4.8 out of 5 stars
1,357 Reviews

MigreLief Original Formula

#1 nutritional supplement for teen and adult migraine sufferers.

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Effective Nutritional Support for Migraine Sufferers*

The power of nutrients is often overlooked when considering effective solutions for migraine sufferers.* Original patented triple-therapy formula has been widely recommended by neurologists, headache specialists, and healthcare practitioners for over twenty-five years.

  • Drug-free
  • Effective and safe for long-term, daily use by adults and teens
  • Researched and developed by Akeso Health Sciences' Chief Scientific Officer, Curt Hendrix, MS, CCN, CNS, a research scientist who holds degrees in chemistry and clinical nutrition and is a Clinical Nutrition Specialist.
  • Manufactured in an established GMP facility; third party quality testing
  • NO butterbur, wheat, gluten, salt, soy, milk or dairy, nuts, corn, caffeine, or artificial flavorings or preservatives; non-GMO and vegan

MigreLief® IS A TRUSTED FORMULA THAT MAKES A DIFFERENCE

Learn More in our Health Library

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

MigreLief® products have changed lives worldwide by providing effective nutritional support to migraine sufferers. 

Original Patented Formula with Puracol : 60 Caplets / 2 per day / 1-month supply

Amount per 2 Tablets Daily Value
Riboflavin (Vitamin B-2) 400mg 23,529%
Magnesium (as citrate and oxide) 360mg 90%
Puracol® Feverfew** (Tanacetum parthenium) 100mg *
*No Daily Value established

**Puracol® Feverfew (Tanacetum parthenium) is unique to MigreLief. Delivered in optimum, clinically-studied amounts, Akeso’s Puracol® is a proprietary combination of whole leaf feverfew high in naturally occurring phytochemicals and a special feverfew extract. Supports proper cerebrovascular tone and function, and platelet aggregation that can otherwise lead to vasoconstriction.*

Magnesium—two clinically known beneficial forms of magnesium in daily amounts critical to controlling the inhibition of vasospasm and platelet aggregation in support of cerebral vascular tone*

Riboflavin (vitamin B-2)—although necessary for human health, riboflavin is not produced by the body and, therefore, must come from our food or dietary supplementation; high doses of highly absorbable Riboflavin have been proven in clinical studies to reduce the number of neurological discomforts experienced each month and to improve mitochondrial energy deficiencies*

MigreLief “Original” – Effective for adults and teens ages 13 and older

Take 1 caplet in the morning and 1 caplet in the afternoon or evening with food. Allow six to seven hours between servings.

Continue daily use after 90 day build-up period to maintain benefits. Many see benefits starting within a few days.

CAUTION: Not for use during pregnancy, during lactation or by children under 13 years of age. (For children age 2-12 consider Children's MigreLief)

  • Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
  • Although rare, some individuals experience transient (short term) diarrhea when taking magnesium.
  • Like most dietary supplements, use of MigreLief should be discontinued one week before any surgery.


You have a choice of MigreLief® daily formulas:

MigreLief “Original” – Effective for adults and teens ages 13 and older

MigreLief+M – For women experiencing hormonal/menstrual related neurologic discomfort

Children’s MigreLief – Parents #1 choice for ages 2 - 12 years—a safe, effective, and gentle option

Choose MigreLief-NOW for fast-acting, as-needed neurological comfort. Safe and effective for both adults and children age 2 and older. MigreLief-NOW may be combined with any of the other daily MigreLief formulas.

  1. Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
  2. Lawrence Review of Natural Products, September 1994.
  3. Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
  4. Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
  5. Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Phrm Pharmacol 1988; 40-743-5
  6. Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
  7. Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
  8. Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
  9. Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
  10. Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
  11. Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
  12. Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
  13. Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
  14. Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
  15. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
  16. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine Cephalalgia 1996;16;436-40
  17. Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
  18. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
  19. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
  20. Maria Condò, Annio Posar, Annalisa Arbizzani and Antonia Parmeggiani Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009.

Nutritional Support That Works With Your Body

MigreLief provides nutritional support for migraine sufferers.

Card Image
To Begin

Take one caplet every morning and evening for best results.

Days 1-90

Give your body time to absorb the essential nutrients to feel the benefits.

90 Days Later

Continue daily use after 90-day build-up period to maintain benefits.

Unique, Tested & Guaranteed

  • Researched and developed by Akeso Health Sciences' Chief Scientific Officer: Our advanced formula was created by Curt Hendrix, MS, CCN, CNS - a pioneer in natural health solutions.
  • Clinically Studied Ingredients: Formulated with magnesium, riboflavin, and Puracol® Feverfew - ingredients backed by scientific research.
  • Unique Puracol® Feverfew: A proprietary blend delivering optimal support for cerebrovascular tone and function.*
  • Satisfaction Guaranteed: Backed by our 90-Day Customer Satisfaction Guarantee.

Original Patented Formula Trusted Worldwide

+
Puracol® Feverfew

Puracol® Feverfew

Encourages a healthy inflammatory response, proper cerebrovascular tone and function & normal platelet aggregation.

Puracol® Feverfew

Encourages a healthy inflammatory response, proper cerebrovascular tone and function & normal platelet aggregation.

+
Magnesium

Magnesium

Supports muscle relaxation, nerve function & brain health.

Magnesium

Supports muscle relaxation, nerve function & brain health.

+
Riboflavin (Vitamin B-2)

Riboflavin (Vitamin B-2)

Promotes mitochondrial energy production & healthy brain cell function.

Riboflavin (Vitamin B-2)

Promotes mitochondrial energy production & healthy brain cell function.

Frequently Asked Questions

Which MigreLief formula is right for me?

The MigreLief line consists of three daily maintenance formulas and one fast-acting / as needed formula.

  • MigreLief Original – Daily nutritional support for adult and teen migraine sufferers who want ongoing, long-lasting benefits. Supports healthy: cerebrovascular tone and function, mitochondrial energy, and healthy inflammatory response.
  • MigreLief+M - Daily nutritional support for those who know their migraines are menstrually/hormonally related (occur at the same time each month either before, during or after your period).
  • Children's MigreLief – Daily nutritional support for kids age 2-12 with migraine. Smaller caplets than Original MigreLief and lower dose. May crush caplet and mix with food for easier swallowing. If you are a child (age 2–12) with migraines and need a gentle version: go with Children’s MigreLief.
  • MigreLief-NOW – Taken as needed for fast-acting nutritional support. May combine with any daily MigreLief formula. If you need on-the-spot or “as needed” support (not just daily) when migraine symptoms first strike: use
What does MigreLief contain (ingredients)?

MigreLief is a drug-free, caffeine-free, dietary supplement.

  • MigreLief Original: Each 2-caplet daily dose contains Riboflavin (Vitamin B-2) 400 mg, Magnesium (as citrate + oxide) 360 mg, and Puracol® Feverfew 100 mg.
  • Children's MigreLief: (2-caplet daily dose for children ages 2-12): Riboflavin 200 mg, Magnesium 180 mg, Puracol® Feverfew 50 mg.
  • MigreLief +M: Same triple therapy ingredients as Original MigreLief (Magnesium 360 mg, Riboflavin 400 mg, and Puracol Feverfew 100 mg) + 5 additional for menstrual migraine sufferers: Vitamin B6 100 mg, Biotin 15 mg, Chasteberry Extract 275 mg, L-Theanine 100 mg, and Chromium Picolinate 1,000 mcg) for women with menstrual/hormonal migraines.
  • MigreLief-NOW: (fast-acting): 2 capsules contain: Cerevasc Ginger 500 mg, Puracol Feverfew 100 mg, Aflapin Boswellia Serrata 100 mg, and Magnesium 180 mg for as-needed nutritional support, as-needed.
How should I use MigreLief? What is dosage and timing?
  • For daily MigreLief formulas (Original/Children's/+M): Take 1 caplet in the morning and 1 caplet in the afternoon or evening with food. Allow about 6–7 hours between servings.
  • For MigreLief-NOW (as needed): Take with food at the first sign of discomfort; for ages 14+ (adult) a common guideline is 3-4 capsules, and you may repeat it in 2 hours if needed. Do not exceed 8 capsules in 24 hours
  • Ages 9-13: Take 1-2 capsules with food. May repeat dose in 2 hours. Do not exceed 4 capsules in a 24-hour period. Do not exceed 2 capsules if combining with a MigreLief daily formula.
  • Ages 2-8: Take 1 capsule with food. May repeat dose in 2 hours. Do not exceed 2 capsules in a 24-hour period.
How quickly will I see results? When will I know it’s working?

While many people experience benefits in under 3 weeks, MigreLief daily formulas were designed to reach maximum benefits within a 90-day build-up period. Daily use and consistency are key!

Are there any MigreLief side-effects?

There are no harmful side-effects generally associated with MigreLief when used as directed. If allergic to any of the ingredients, discontinue use.

  • Riboflavin (vitamin B2) can cause the urine to become bright yellow. This is harmless.
  • Some people taking magnesium for the first time may experience loose stools or transient diarrhea; usually stops once the body adjusts.
  • Because feverfew is an herb in the daisy/ragweed family, if someone is allergic to ragweed or similar plants, there could be sensitivity.

General advice: as with many supplements, discontinue use 7 days before surgery.

Can I take MigreLief with migraine medications?

It is always best to check with your healthcare professional before starting any new supplement regimen. MigreLief does not interfere with migraine drugs.

Is MigreLief drug-free

Yes, MigreLief is drug-free and does not contain caffeine.

Can children take MigreLief? At what age?

Yes. Children’s MigreLief is designed just for kids ages 2-12. Pill sizes and dosages are smaller. The caplets can also be crushed and mixed with food for easier swallowing.

What is the guarantee / refund policy?

MigreLief products come with a 90-day satisfaction guarantee when purchased at MigreLief.com. Use the product as directed, over a period of 90 days (3 months)— if you are not satisfied for any reason, your purchase price will be refunded. Refund policy:
https://migrelief.com/refund-policy/

How long should I use MigreLief? Is it safe for long-term use?

For best results, use any MigreLief daily formula for 90 days (the buildup period for maximum benefits). MigreLief is safe for long-term use. MigreLief-NOW, the as-needed formula can also be used daily for additional ongoing nutritional support, or as-needed (at first signs of discomfort).

You Have a Choice of MigreLief Formulas

MigreLief Original Formula Product Photo

MigreLief Original

MigreLief+M Product Photo

MigreLief + M

MigreLief-NOW Product Photo

MigreLief Now

Children’s MigreLief Product Photo

Children’s MigreLief

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Product Description
Daily nutritional support for teen and adult migraine sufferers.
Designed for women who experience hormonal migraines.
Fast-acting, on-the-spot nutritional support when migraines strike.
Recommended by pediatric neurologists, with child-friendly caplets for easy use.
Safe, Effective & Drug-Free
Clinically Backed Ingredients
Third-Party Tested
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Trusted By Thousands

Reviews Disclaimer

The product reviews below are not a substitute for professional medical advice, diagnosis, or treatment. The opinions below reflect the views and opinions expressed by our customers and not those of MigreLief, and are provided for informational purposes only. We do not verify or endorse any claims made in these reviews.

4.8
Rated 4.8 out of 5 stars
Based on 1,357 reviews
96%would recommend these products
Total 5 star reviews: 1.1k Total 4 star reviews: 159 Total 3 star reviews: 44 Total 2 star reviews: 5 Total 1 star reviews: 2
1,357 reviews
  • Silvia
    Reviewing
    MigreLief-NOW
    I recommend this product
    Rated 5 out of 5 stars
    5 Stars

    Just what I ordered.

  • Bonnie
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    5 Stars

    I take these on a daily basis and my margarines are gone. I have been taking them for 6 months now and I'm still so very impressed by how well they work!

  • Gloria P.
    Verified Buyer
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    Original

    it is very good, love all your stuff

  • Annee H.
    Verified Buyer
    Reviewing
    MigreLief+M
    I recommend this product
    Rated 5 out of 5 stars
    Game changer

    I absolutely love my migrelief. At this point if I missed a dose or I run out I can definitely tell the difference. This has become a part of my daily routine

  • Barbara A.
    Verified Buyer
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    This has helped so much!

    My son started taking this after his neurologist suggested it. It is great!

Created by the Pioneer of Migraine Supplements

Created by the Pioneer of Migraine Supplements

Based on scientific evidence, MigreLief’s Chief Scientific Officer, Curt Hendrix, MS, CCN, CNS, was the first to discover the unique combination of magnesium, riboflavin (vitamin B2), and Puracol® feverfew for migraine sufferers, earning him two U.S. patents.


Passionate and driven, Curt’s mission is to empower people with better, more natural ways to support their well-being.