Summary
Product information
Ingredients
Recommended Usage
Side Effects
References
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MigreLief-NOW is a non-prescription nutritional supplement recommended by healthcare professionals. It provides fast acting nutritional support to migraine and headache sufferers when they need it most, NOW! Not just for migraines and headaches, MigreLief-NOW is truly a powerful force for promoting wellness and comfort in your body.

MigreLief-NOW provides fast-acting, drug-free cerebrovascular support and is safe for men, women and children age 2 or older, NOW may be used by itself or combined with any other MigreLief daily maintenance formula as necessary, or DAILY for additional nutritional benefits. See usage tab above or label for recommended dosages by age.

NOW contains Magnesium (citrate and oxide), Puracol Feverfew, a proprietary combination of whole leaf feverfew containing a broad spectrum of naturally occurring phytochemicals and a unique feverfew leaf extract, Cerevasc Ginger, a proprietary combination of ginger rhizome powder and standardized ginger extract and Aflapin Boswellia Serrata.

These ingredients have been shown in human clinical studies to have numerous health benefits including benefits for migraine and headache sufferers.

MigreLief-NOW combines all four of these ingredients into one convenient formula. With “NOW” you need only one product instead of 4 separate products.

MigreLief-NOW is drug-free. No prescription necessary.

For more information, click on the Product Information tab.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

MigreLief-NOW is a non-prescription fast-acting drug-free dietary supplement for cerebrovascular support during challenging times. MigreLief-NOW may be used by itself at the first sign of discomfort, combined with any other MigreLief formula as necessary, or used DAILY for additional nutritional support.

MigreLief-NOW is drug-free and contains NO aspirin, acetaminophen, ibuprofen, Naproxen, caffeine or butterbur.
No prescription necessary. Does not interfere with prescription or OTC migraine drugs.

Supplement Facts
(2 capsules per serving) Amount Per Serving

Magnesium (citrate and oxide)	180mg
Puracol Feverfew (whole leaf & extract)**	50mg
Cerevasc Ginger (root powder & extract)***	500mg
Aflapin® Boswellia Serrata (extract) ****	100mg

Does not contain:
Aspirin, caffeine, yeast, wheat, corn, milk, gluten, soy, salt, artificial colorings or flavorings.

** Puracol is a proprietary combination of whole leaf feverfew that contains a broad spectrum of naturally occurring phytochemicals and a unique feverfew extract.
***Cerevasc Ginger is a proprietary combination of ginger rhizome powder and standardized ginger extract
****Aflapin® is a registered trademark of Laila Nutraceuticals. International patents pending.

Other Ingredients: Powdered cellulose, silicon dioxide, magnesium stearate, HPMC (shell), titanium dioxide (shell), caramel color (shell).

Not just for migraines, MigreLief-Now is truly a powerful force for promoting wellness and comfort in your body.

Note: For chronic migraine sufferers, MigreLief-NOW is not meant to replace the other MigreLief long-term daily maintenance formulas. NOW should be kept on hand in case of migraine and headache occurrences when same-day help is needed. If you suffer multiple migraines a month, taking one of the regular daily MigreLief formulas (Original, Menstrual or Children’s) is recommended. If you are taking a daily MigreLief formula, and still feel you need additional support, consider adding MigreLief-NOW to the morning dose of your daily MigreLief regimen, in addition to taking NOW on those challenging days when needed.

CLINICAL STUDIES: Ginger, Boswellia, Feverfew and Magnesium

This product is not intended to diagnose, treat, cure or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Cerevasc Ginger

MigreLief-NOW’s proprietary blend of two ginger sources. Ginger has been used as an ethnobotanical for hundreds of years. Now even conventional, allopathic clinicians and researchers are starting to recognize its medicinal benefits. Ginger contains more than 200 substances in its oils, which is why it has so many different uses. Ginger’s significant anti-inflammatory benefits have led to many clinical studies supporting its use.

Specific compounds in ginger are thought to be responsible for much of ginger’s beneficial activities. Trying to extract ginger to maximize these compounds could be beneficial but may also disrupt the balance of other ginger compounds that we are either not aware of or don’t understand as well.

We wanted to make sure that all of the naturally occurring ginger compounds are present in MigreLief-NOW. Therefore, similarly to Puracol Feverfew, Akeso chose to include both a specific ginger powder and combine it with a specific proprietary ginger extract, and thus created Cerevasc ginger. This assures both the proper ratios and quantities of those naturally occurring phytochemical in ginger that we believe are responsible for it multiple health benefits.

Akeso Health Sciences has worked hard to gain an understanding of how the compounds in ginger work, which ones are most potent and beneficial and is filing patents on methods to maximize the presence and ratios of the naturally occurring compounds.

Aflapin Boswellia Serrata Extract

A proprietary licensed nutraceutical containing Boswellia extract from Laila Pharmaceuticals of India, has been shown in clinical studies to have great health benefits. The active ingredients are referred to as boswellic acids, with beta boswellic acid being the major component. The absorption of boswellic acids is less than ideal, thereby necessitating processing regimens that enhance their absorption. Until the advent of Aflapin due to poor absorption of the active boswellic acids, doses of 500-1,500 mg/day were necessary to achieve sufficient analgesic relief. Because of the patented processing of Aflapin the therapeutic dose is down to 100-200 mg/day and compared to standard boswellia products, has been shown to be superior.

Boswellia is one of the true go to herbals medicines used by Ayurvedic physicians and now recent clinical studies are confirming what has been known for over 500 years in India.

Feverfew (Tanacetum parthenium)

Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness for migraines.(1-10) Some studies of extracts of feverfew containing higher parthenolide levels yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be combination of specific feverfew extract and whole leaf source that contained high levels of parthenolide yet kept all of the other naturally occurring phytochemicals as well, some of which may be eliminated in an extracted product. Thus, Puracol Feverfew (AKESO HEALTH SCIENCE’S proprietary feverfew source) was developed. Puracol Feverfew, is just one of the reasons for the superior benefits of MigreLief. Akeso is a leader in feverfew research and is working to further elucidate the mechanisms of action of feverfew in the near future.

Magnesium

Research studies show that almost half of all migraine sufferers have low blood levels of magnesium – which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines).

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium.(11-16) Recommended daily dosages of magnesium typically range from 360 to 600 mg to compensate for this deficiency — far above what’s found in most multi-vitamins.

CLINICAL STUDIES: Ginger, Boswellia, Feverfew and Magnesium

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

MigreLief-NOW is to be taken “AS NEEDED” for fast-acting nutritional and cerebrovascular support during challenging times. It may be used by itself on an “as needed” basis, or combined with any other MigreLief formula AS NEEDED OR DAILY for additional nutritional support.

As early as possible, at the first signs of discomfort, take MigreLief-NOW capsules with food:
Age 14-Adult (Take 3-4 capsules with food. May repeat dose in 2 hrs. No more than 8 capsules in a 24 hr. period or 4 if combining with a MigreLief daily formula.)
Age 9-13 (Take 1-2 capsules with food. May repeat in 2 hrs. No more than 4 capsules in a 24 hr. period or 2 if combining with a MigreLief daily formula.)
Age 2-8 (Take 1 capsule with food. May repeat dose in 2 hrs.) No more than 2 capsules in a 24 hour period.)

“NOW” may be used by men, women and children 12 years or older.
Half of the adult dose may be used by children between ages 2 – 12.

Warning: Not for use during pregnancy, during lactation or by children under 2 years of age.

MigreLief-NOW is drug-free. No prescription necessary.

Like most dietary supplements, use of MigreLief-NOW should be discontinued one week before surgery to reduce the risk of excessive bleeding.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Potential side effects, though rare, can be:

1 – An individual being allergic to any of the ingredients in MigreLief+M. If you are allergic to any of the ingredients, cease taking the product.
2 – Some individuals may experience transient diarrhea when ingesting magnesium.
3 – Some individuals can experience gastro-intestinal upset when taking dietary supplements.
4 – Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
5 – Though rare, some people can feel achy, tired and experience a headache if they abruptly stop taking feverfew. It is recommended that you taper off gradually, cutting the dose down to one daily for a week, then down to one every other day for a week, and then stop.
6 – Like most dietary supplements, use of MigreLief should be discontinued one week before surgery to reduce the risk of excessive bleeding.

Warning: Not for use during pregnancy or lactation.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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