4.8
Rated 4.8 out of 5 stars
1,357 Reviews

MigreLief Original Formula Travel Size

Nutritional support for teens and adults suffering with migraines*

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Effective Nutritional Support for Migraine Sufferers*

The power of nutrients is often overlooked when considering effective solutions for migraine sufferers.* Original patented triple-therapy formula has been widely recommended by neurologists, headache specialists, and healthcare practitioners for over twenty-five years.

  • Drug-free
  • Effective and safe for long-term, daily use by adults and teens
  • Researched and developed by Akeso Health Sciences' Chief Scientific Officer, Curt Hendrix, MS, CCN, CNS, a research scientist who holds degrees in chemistry and clinical nutrition and is a Clinical Nutrition Specialist.
  • Manufactured in an established GMP facility; third party quality testing
  • NO butterbur, wheat, gluten, salt, soy, milk or dairy, nuts, corn, caffeine, or artificial flavorings or preservatives; non-GMO and vegan

MigreLief® IS A TRUSTED FORMULA THAT MAKES A DIFFERENCE

Learn More in our Health Library

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

MigreLief® IS A TRUSTED FORMULA THAT MAKES A DIFFERENCE

Akeso's MigreLief® line of products has successfully been used by hundreds of thousands of customers worldwide for more than 2 decades.

MigreLief® - Original Patented Formula with Puracol®

60 Caplets / 2 per day / 1-month supply

Amount per 2 Tablets Daily Value
Riboflavin (Vitamin B-2) 400mg 23,529%
Magnesium (as citrate and oxide) 360mg 90%
Puracol® Feverfew** (Tanacetum parthenium) 100mg *

*No Daily Value established

**Puracol® Feverfew is a proprietary combination of whole leaf feverfew that is high in naturally occurring phytochemicals and a special feverfew extract. Feverfew is shown to inhibit histamine release and platelet aggregation leading to vasoconstriction*

Magnesium—two clinically known beneficial forms of magnesium in daily amounts critical to controlling the inhibition of vasospasm and platelet aggregation in support of cerebral vascular tone*

Riboflavin (vitamin B-2)—although necessary for human health, riboflavin is not produced by the body and, therefore, must come from our food or dietary supplementation; high doses of highly absorbable Riboflavin have been proven in clinical studies to reduce the number of neurological discomforts experienced each month and to improve mitochondrial energy deficiencies*

The MigreLief Nutritional Regimen


Choose one of our MigreLief® daily formulas & take every day:

MigreLief “Original” – Effective for adults and teens, ages 12 and older

MigreLief+M – For women experiencing hormonal/menstrual related neurologic discomfort

Children’s MigreLief – Parents #1 choice for ages 2 - 12 years—a safe, gentle, natural option

Take 2 per day, every day (1 in a.m. and 1 in p.m). Although most see benefits within a few days, these products are designed to provide full benefits within a 90-day build-up period. To maintain benefits thereafter, continue daily use.

And/or choose MigreLief-NOW for fast-acting, as-needed neurological comfort. Safe and effective for both adults and children age 2 and older. MigreLief-NOW may be combined with any of the other daily MigreLief formulas.

Caution: Not for use during pregnancy, during lactation or by children under 2 years of age.

Please note:

  • Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
  • Although rare, some individuals experience transient (short term) diarrhea at first when taking magnesium.

Like most dietary supplements, use ofMigreLiefshould be discontinued one week before any surgery.

  1. Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
  2. Lawrence Review of Natural Products, September 1994.
  3. Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
  4. Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
  5. Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Phrm Pharmacol 1988; 40-743-5
  6. Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
  7. Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
  8. Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
  9. Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
  10. Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
  11. Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
  12. Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
  13. Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
  14. Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
  15. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
  16. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine Cephalalgia 1996;16;436-40
  17. Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
  18. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
  19. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
  20. Maria Condò, Annio Posar, Annalisa Arbizzani and Antonia Parmeggiani Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009.
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Migraine Support You Deserve

  • Safe for long-term, daily use by adults and teens.
  • All vegan, non-dairy, and gluten-free ingredients.
  • Produced without genetic engineering or GMO ingredients.
  • Nutritional support for teens and adults suffering with migraines*
  • Original formula with Riboflavin, Magnesium and Puracol® Feverfew
  • Effective long-term triple therapy support*
  • Widely recommended by neurologists and headache specialists
  • Formulated by original patent holder and Chief Scientific Officer, Curt Hendrix

Frequently Asked Questions

Which MigreLief formula is right for me?

The MigreLief line consists of three daily maintenance formulas and one fast-acting / as needed formula.

  • MigreLief Original – Daily nutritional support for adult and teen migraine sufferers who want ongoing, long-lasting benefits. Supports healthy: cerebrovascular tone and function, mitochondrial energy, and healthy inflammatory response.
  • MigreLief+M - Daily nutritional support for those who know their migraines are menstrually/hormonally related (occur at the same time each month either before, during or after your period).
  • Children's MigreLief – Daily nutritional support for kids age 2-12 with migraine. Smaller caplets than Original MigreLief and lower dose. May crush caplet and mix with food for easier swallowing. If you are a child (age 2–12) with migraines and need a gentle version: go with Children’s MigreLief.
  • MigreLief-NOW – Taken as needed for fast-acting nutritional support. May combine with any daily MigreLief formula. If you need on-the-spot or “as needed” support (not just daily) when migraine symptoms first strike: use
What does MigreLief contain (ingredients)?

MigreLief is a drug-free, caffeine-free, dietary supplement.

  • MigreLief Original: Each 2-caplet daily dose contains Riboflavin (Vitamin B-2) 400 mg, Magnesium (as citrate + oxide) 360 mg, and Puracol® Feverfew 100 mg.
  • Children's MigreLief: (2-caplet daily dose for children ages 2-12): Riboflavin 200 mg, Magnesium 180 mg, Puracol® Feverfew 50 mg.
  • MigreLief +M: Same triple therapy ingredients as Original MigreLief (Magnesium 360 mg, Riboflavin 400 mg, and Puracol Feverfew 100 mg) + 5 additional for menstrual migraine sufferers: Vitamin B6 100 mg, Biotin 15 mg, Chasteberry Extract 275 mg, L-Theanine 100 mg, and Chromium Picolinate 1,000 mcg) for women with menstrual/hormonal migraines.
  • MigreLief-NOW: (fast-acting): 2 capsules contain: Cerevasc Ginger 500 mg, Puracol Feverfew 100 mg, Aflapin Boswellia Serrata 100 mg, and Magnesium 180 mg for as-needed nutritional support, as-needed.
How should I use MigreLief? What is dosage and timing?
  • For daily MigreLief formulas (Original/Children's/+M): Take 1 caplet in the morning and 1 caplet in the afternoon or evening with food. Allow about 6–7 hours between servings.
  • For MigreLief-NOW (as needed): Take with food at the first sign of discomfort; for ages 14+ (adult) a common guideline is 3-4 capsules, and you may repeat it in 2 hours if needed. Do not exceed 8 capsules in 24 hours
  • Ages 9-13: Take 1-2 capsules with food. May repeat dose in 2 hours. Do not exceed 4 capsules in a 24-hour period. Do not exceed 2 capsules if combining with a MigreLief daily formula.
  • Ages 2-8: Take 1 capsule with food. May repeat dose in 2 hours. Do not exceed 2 capsules in a 24-hour period.
How quickly will I see results? When will I know it’s working?

While many people experience benefits in under 3 weeks, MigreLief daily formulas were designed to reach maximum benefits within a 90-day build-up period. Daily use and consistency are key!

Are there any MigreLief side-effects?

There are no harmful side-effects generally associated with MigreLief when used as directed. If allergic to any of the ingredients, discontinue use.

  • Riboflavin (vitamin B2) can cause the urine to become bright yellow. This is harmless.
  • Some people taking magnesium for the first time may experience loose stools or transient diarrhea; usually stops once the body adjusts.
  • Because feverfew is an herb in the daisy/ragweed family, if someone is allergic to ragweed or similar plants, there could be sensitivity.

General advice: as with many supplements, discontinue use 7 days before surgery.

Can I take MigreLief with migraine medications?

It is always best to check with your healthcare professional before starting any new supplement regimen. MigreLief does not interfere with migraine drugs.

Is MigreLief drug-free

Yes, MigreLief is drug-free and does not contain caffeine.

Can children take MigreLief? At what age?

Yes. Children’s MigreLief is designed just for kids ages 2-12. Pill sizes and dosages are smaller. The caplets can also be crushed and mixed with food for easier swallowing.

What is the guarantee / refund policy?

MigreLief products come with a 90-day satisfaction guarantee when purchased at MigreLief.com. Use the product as directed, over a period of 90 days (3 months)— if you are not satisfied for any reason, your purchase price will be refunded. Refund policy:
https://migrelief.com/refund-policy/

How long should I use MigreLief? Is it safe for long-term use?

For best results, use any MigreLief daily formula for 90 days (the buildup period for maximum benefits). MigreLief is safe for long-term use. MigreLief-NOW, the as-needed formula can also be used daily for additional ongoing nutritional support, or as-needed (at first signs of discomfort).

You Have a Choice of Four MigreLief Formulas

MigreLief Original Formula Product Photo

MigreLief Original

MigreLief-NOW Product Photo

MigreLief Now

MigreLief+M Product Photo

MigreLief + M

Children's MigreLief Product Photo

Children's MigreLief

Product Description
Daily nutritional support for teen and adult migraine sufferers*
As-needed nutritional support for migraine or headache sufferers.
Daily nutritional support for menstrual/hormonal migrain sufferers*
Daily nutritional support for pediatric migraine sufferers age 2-12*
Safe & Effective
Safe and effective for daily use – drug free
Safe and effective for on-the-spot use – drug free
Safe and effective for daily use — drug free
Same triple-therapy formula as Original MigreLief with doses adjusted for children.
Formula Type
Triple-therapy formula
Fast-acting formula
Triple-therapy formula PLUS 5 additional blood sugar and hormone modulating ingredients.
Same triple-action ingredients as original patented MigreLief
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Trusted By Thousands

Reviews Disclaimer

The product reviews below are not a substitute for professional medical advice, diagnosis, or treatment. The opinions below reflect the views and opinions expressed by our customers and not those of MigreLief, and are provided for informational purposes only. We do not verify or endorse any claims made in these reviews.

4.8
Rated 4.8 out of 5 stars
Based on 1,357 reviews
96%would recommend these products
Total 5 star reviews: 1.1k Total 4 star reviews: 159 Total 3 star reviews: 44 Total 2 star reviews: 5 Total 1 star reviews: 2
1,357 reviews
  • Silvia
    Reviewing
    MigreLief-NOW
    I recommend this product
    Rated 5 out of 5 stars
    5 Stars

    Just what I ordered.

  • Bonnie
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    5 Stars

    I take these on a daily basis and my margarines are gone. I have been taking them for 6 months now and I'm still so very impressed by how well they work!

  • Gloria P.
    Verified Buyer
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    Original

    it is very good, love all your stuff

  • Annee H.
    Verified Buyer
    Reviewing
    MigreLief+M
    I recommend this product
    Rated 5 out of 5 stars
    Game changer

    I absolutely love my migrelief. At this point if I missed a dose or I run out I can definitely tell the difference. This has become a part of my daily routine

  • Barbara A.
    Verified Buyer
    Reviewing
    MigreLief Original Formula
    I recommend this product
    Rated 5 out of 5 stars
    This has helped so much!

    My son started taking this after his neurologist suggested it. It is great!

Curt Hendrix, MS, CCN, CNS

Curt Hendrix, MS, CCN, CNS

Curt, our co-founder, is passionate about helping people with chronic health issues. He has dedicated his life to the research and development of natural medicines. With degrees in chemistry and clinical nutrition, Curt has been studying the chemistry of disease for over 30 years.


Researchers around the world cite Curt's published scientific research. He is well known for his extensive knowledge in the field of neurological disorders, including Alzheimer's. The U.S. National Institutes of Health trusted Curt with several grants and patents.


Curt believes that evidence-based science is the key to effective natural medicines.