4.9
Rated 4.9 out of 5 stars
7 Reviews

Akeso's Age-Defying Botanical Night Serum

Natural and healthy antioxidant-rich nourishment for a youthful, glowing, and healthy appearance.

Size
Size
Frequency
In Stock. Free shipping on orders over $40
Product image

Restore your skin back to a youthful glow with Akeso's Age-Defying Botanical Night Serum – a combination of the world’s best-known moisturizing and anti-aging ingredients.

Akeso's Age-Defying Botanical Night Serum combines retinol and powerful botanicals clinically proven to moisturize the skin and reduce the appearance of wrinkles and other signs of aging.

 

Frequently Asked Questions

What does Akeso Age-Defying Botanical Night Serum do?

Akeso's Age-Defying Botanical Night Serum is a rich, retinol-based botanical formula designed to visibly reduce the appearance of fine lines and wrinkles, improve firmness, and restore a more youthful, radiant glow while you sleep. It combines encapsulated retinol with advanced moisturizers, peptides, antioxidants, and plant extracts to support smoother, healthier-looking skin overnight.

What are the key ingredients and how do they work?

This night serum features liposomal retinol for gentle exfoliation and cell turnover, Aquaxyl™, hyaluronic acid, shea butter, and aloe vera for deep hydration, and peptide complexes like Matrixyl® and Matrixyl® Synthe-6™ to help support collagen and elastin for firmer skin. It also includes stabilized vitamin C, apple stem cell extract, green tea, chamomile, and olive leaf extracts to brighten skin tone, protect against environmental damage, and calm visible redness for a more even, youthful complexion.

How do I use the serum in my nightly routine?

Apply a small amount to clean, dry face, neck, and décolletage in the evening, avoiding direct contact with the eyes.

Is it suitable for sensitive skin, and how soon will I see results?

The formula uses encapsulated (liposomal) retinol and soothing botanicals like aloe and chamomile to help minimize irritation while still delivering visible anti-aging benefits. Many users notice softer, more hydrated skin quickly, with improvements in texture, radiance, and the look of fine lines appearing gradually over several weeks of consistent nightly use.

You Have a Choice of Four MigreLief Formulas

MigreLief Original Formula Product Photo

Daily nutritional support for teen and adult migraine sufferers*

Safe and effective for daily use – drug free

Triple-therapy formula

View Product Details Add to Cart
MigreLief-NOW Product Photo

As-needed nutritional support for migraine or headache sufferers.

Safe and effective for on-the-spot use – drug free

Fast-acting formula

View Product Details Add to Cart
MigreLief+M Product Photo

Daily nutritional support for menstrual/hormonal migrain sufferers*

Safe and effective for daily use — drug free

Triple-therapy formula PLUS 5 additional blood sugar and hormone modulating ingredients.

View Product Details Add to Cart
Children’s MigreLief Product Photo

Daily nutritional support for pediatric migraine sufferers age 2-12*

Same triple-therapy formula as Original MigreLief with doses adjusted for children.

Same triple-action ingredients as original patented MigreLief

View Product Details Add to Cart

Trusted By Thousands

Reviews Disclaimer

The product reviews below are not a substitute for professional medical advice, diagnosis, or treatment. The opinions below reflect the views and opinions expressed by our customers and not those of MigreLief, and are provided for informational purposes only. We do not verify or endorse any claims made in these reviews.

4.9
Rated 4.9 out of 5 stars
Based on 7 reviews
100%would recommend this product
Total 5 star reviews: 6 Total 4 star reviews: 1 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
7 reviews
  • Diane R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Night Serum

    I am a Cosmetologist/Esthetician and would like to let you know how good the Akeso’s Age-Defying Botanical Night Serum is. I have been seeing and working on many skin types throughout the years and find this serum to be excellent .

    My advice is to try it. It always takes a few months to see improvements in the skin and also with Hair Growth.. Take a picture before you start, two months later, and four months later and see the improvement.

    Have a beautiful day !

    Diane R. Emmaus,PA

  • Amelia R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Great Product

    I started using this a year ago and have really seen an improvement in my skin. I feel like akeso is known for their organic products and feel good using this knowing there is not a lot of unnecessary additions.

  • Bradford W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Cheaper and works really well

    When I hit 50 I suddenly started paying attention. This stuff works great.

  • Oksana B.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Night Serum

    This serum is amazing! It absorb quick into skin, it doesn't stay on the surface like another moisturizers.

    The serum doesn't peel your skin as a regular retinal serum or cream.

    I see the result after 1st week already.

    I'll buy again.

  • Eva P.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    A satisfied customer

    I have adult acne which flares up in Aug. Since I've been using the Night Serum I have not had any flare ups. I had a very expensive cream that was made in Chandler, AZ and was only slightly effective, so I am very pleased with your product.

Curt Hendrix, MS, CCN, CNS

Curt Hendrix, MS, CCN, CNS

Curt, our co-founder, is passionate about helping people with chronic health issues. He has dedicated his life to the research and development of natural medicines. With degrees in chemistry and clinical nutrition, Curt has been studying the chemistry of disease for over 30 years.


Researchers around the world cite Curt's published scientific research. He is well known for his extensive knowledge in the field of neurological disorders, including Alzheimer's. The U.S. National Institutes of Health trusted Curt with several grants and patents.


Curt believes that evidence-based science is the key to effective natural medicines.