MigreLief Original Formula
#1 nutritional supplement for teen and adult migraine sufferers.
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Original patented triple-therapy formula
- Trusted by neurologists for over 25 years
- Clinically proven ingredients to support head comfort
Product Information
Effective Nutritional Support for Migraine Sufferers*
The power of nutrients is often overlooked when considering effective solutions for migraine sufferers.* Original patented triple-therapy formula has been widely recommended by neurologists, headache specialists, and healthcare practitioners for over twenty-five years.
- Drug-free
- Effective and safe for long-term, daily use by adults and teens
- Researched and developed by Akeso Health Sciences' Chief Scientific Officer, Curt Hendrix, MS, CCN, CNS, a research scientist who holds degrees in chemistry and clinical nutrition and is a Clinical Nutrition Specialist.
- Manufactured in an established GMP facility; third party quality testing
- NO butterbur, wheat, gluten, salt, soy, milk or dairy, nuts, corn, caffeine, or artificial flavorings or preservatives; non-GMO and vegan
MigreLief® IS A TRUSTED FORMULA THAT MAKES A DIFFERENCE
Learn More in our Health Library
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ingredients
MigreLief® products have changed lives worldwide by providing effective nutritional support to migraine sufferers.
Original Patented Formula with Puracol : 60 Caplets / 2 per day / 1-month supply
Amount per 2 Tablets | Daily Value | |
---|---|---|
Riboflavin (Vitamin B-2) | 400mg | 23,529% |
Magnesium (as citrate and oxide) | 360mg | 90% |
Puracol® Feverfew** (Tanacetum parthenium) | 100mg | * |
*No Daily Value established
**Puracol® Feverfew (Tanacetum parthenium) is unique to MigreLief. Delivered in optimum, clinically-studied amounts, Akeso’s Puracol® is a proprietary combination of whole leaf feverfew high in naturally occurring phytochemicals and a special feverfew extract. Supports proper cerebrovascular tone and function, and platelet aggregation that can otherwise lead to vasoconstriction.*
Magnesium—two clinically known beneficial forms of magnesium in daily amounts critical to controlling the inhibition of vasospasm and platelet aggregation in support of cerebral vascular tone*
Riboflavin (vitamin B-2)—although necessary for human health, riboflavin is not produced by the body and, therefore, must come from our food or dietary supplementation; high doses of highly absorbable Riboflavin have been proven in clinical studies to reduce the number of neurological discomforts experienced each month and to improve mitochondrial energy deficiencies*
Recommended Use
MigreLief “Original” – Effective for adults and teens ages 13 and older
Take 1 caplet in the morning and 1 caplet in the afternoon or evening with food. Allow six to seven hours between servings.
Continue daily use after 90 day build-up period to maintain benefits. Many see benefits starting within a few days.
CAUTION: Not for use during pregnancy, during lactation or by children under 13 years of age. (For children age 2-12 consider Children's MigreLief)
- Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
- Although rare, some individuals experience transient (short term) diarrhea when taking magnesium.
- Like most dietary supplements, use of MigreLief should be discontinued one week before any surgery.
You have a choice of MigreLief® daily formulas:
MigreLief “Original” – Effective for adults and teens ages 13 and older
MigreLief+M – For women experiencing hormonal/menstrual related neurologic discomfort
Children’s MigreLief – Parents #1 choice for ages 2 - 12 years—a safe, effective, and gentle option
Choose MigreLief-NOW for fast-acting, as-needed neurological comfort. Safe and effective for both adults and children age 2 and older. MigreLief-NOW may be combined with any of the other daily MigreLief formulas.
References
- Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
- Lawrence Review of Natural Products, September 1994.
- Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
- Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
- Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Phrm Pharmacol 1988; 40-743-5
- Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
- Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
- Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
- Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
- Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
- Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
- Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
- Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
- Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
- Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
- Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine Cephalalgia 1996;16;436-40
- Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
- Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
- Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
- Maria Condò, Annio Posar, Annalisa Arbizzani and Antonia Parmeggiani Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009.
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Your Partner in Proactive Migraine Care
MigreLief provides nutritional support for migraine sufferers.
Unique, Tested & Guaranteed
- Developed by a Migraine Expert: Our advanced formula was created by Curt Hendrix, MS, CCN, CNS—a pioneer in natural health solutions.
- Clinically Studied Ingredients: Formulated with magnesium, riboflavin, and Puracol® Feverfew—ingredients backed by scientific research.
- Unique Puracol® Feverfew: A proprietary blend delivering optimal support for cerebrovascular tone and function.*
- Satisfaction Guaranteed: Backed by our 90-Day Customer Satisfaction Guarantee.
Original Patented Formula Trusted Worldwide
Encourages a healthy inflammatory response, proper cerebrovascular tone and function & normal platelet aggregation.
Supports muscle relaxation, nerve function & brain health.
Promotes mitochondrial energy production & healthy brain cell function.
Trusted By Hundreds of Thousands
Reviews Disclaimer
The product reviews below are not a substitute for professional medical advice, diagnosis, or treatment. The opinions below reflect the views and opinions expressed by our customers and not those of MigreLief, and are provided for informational purposes only. We do not verify or endorse any claims made in these reviews.
You Have a Choice of MigreLief Formulas

Created by the Pioneer of Migraine Supplements
Based on scientific evidence, MigreLief’s Chief Scientific Officer, Curt Hendrix, MS, CCN, CNS, was the first to discover the unique combination of magnesium, riboflavin (vitamin B2), and Puracol® feverfew for migraine sufferers, earning him two U.S. patents.
Passionate and driven, Curt’s mission is to empower people with better, more natural ways to support their well-being.